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Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus

¹ National Veterinary and Food Research Institute, Department of Virology, PO Box 45, Hämeentie 57, FIN-00581 Helsinki, Finland
² Moredun Research Institute, International Research Centre, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 OPZ, UK
³ Virus Research Unit, Department of Microbiology, University of Otago, Dunedin, New Zealand
⁴ Federal Research Centre for Virus Diseases of Animals, Institute of Immunology, Paul-Ehrlich-Strasse 28, D-72076 Tübingen, Germany
⁵ CSC – Scientific Computing Ltd, PO Box 405, FIN-02101 Espoo, Finland
⁶ National Veterinary and Food Research Institute, Oulu Regional Unit, PO Box 517, FIN-90101 Oulu, Finland

Correspondence
Maria K. Tikkanen
maria.tikkanen{at}eela.fi

Cases of papular stomatitis in Finnish reindeer have been reported for many years. The causative agent was thought to be Orf virus (ORFV), one of the Parapoxviridae, although this assumption was based mainly on clinical symptoms, pathology and electron microscopy. Here sequence analyses of the viral DNA isolated from a recent outbreak of disease in 1999–2000 are presented in comparison to that isolated from earlier outbreaks in 1992–1994. The results show that the virus isolated from the 1999–2000 outbreak is most closely related to Pseudocowpox virus, whereas those from previous years grouped with ORFV. The present study describes a method for genetic characterization and classification of parapoxviruses (PPVs) and provides for the first time an extended phylogenetic analysis of PPVs isolated from Finland, established members of the genus Parapoxvirus and selected members of the subfamily Chordopoxvirinae.

The GenBank accession numbers of the sequences reported in this article are AY453652–AY453689 and AY455291–AY455311.

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