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J Gen Virol 85 (2004), 1445-1450; DOI 10.1099/vir.0.79790-0

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© 2004 Society for General Microbiology

Short Communication

TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells

Klaas Kooistra1, Ying-Hui Zhang1,2, Niek V. Henriquez1, Bertram Weiss3, Dominik Mumberg3 and Mathieu H. M. Noteborn1,2

1 Leadd BV, Leiden, The Netherlands
2 BFSC, Leiden Institute of Chemistry, Leiden University, PO Box 9503, 2300 RA Leiden, The Netherlands
3 Research Laboratories of Schering AG, Berlin, Germany

Correspondence
Mathieu H. M. Noteborn
m.noteborn{at}chem.leidenuniv.nl

TT virus (TTV) is widespread among the global population. Its pathogenic nature is still unclear but TTV seems to be more prevalent in cases of hepatitis than in healthy individuals. TTV harbours similarities to chicken anaemia virus (CAV). Here, the apoptotic potential of a putative TTV-derived 105 aa protein and of the main apoptosis-inducing agent of CAV, Apoptin, is compared. As the putative protein induced apoptosis in various human hepatocellular carcinoma (HCC) cell lines, it was named TTV-derived apoptosis-inducing protein (TAIP). The apoptotic activity of TAIP in HCC lines was comparable with that of Apoptin. Conversely, unlike Apoptin, TAIP induced only low-level apoptosis in several non-HCC human cancer cell lines. The data suggest that TAIP acts in a different way to Apoptin as it is selective to a certain degree for HCC lines. This activity of TAIP, coupled with the heterogeneity of TTV isolates, may help to explain the variable reports of TTV pathogenicity.






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Copyright © 2004 by the Society for General Microbiology.