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Unusually long target site duplications flanking some of the long terminal repeats of human endogenous retrovirus K in the human genome

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russia

Correspondence
Ilgar Z. Mamedov
Imam{at}humgen.siobc.ras.ru

Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4–6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.

Supplementary data associated with this article are available at http://humgen.siobc.ras.ru/supplement/suppl.html.