HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Leis, M. Articles by Stamminger, T. Search for Related Content PubMed PubMed Citation Articles by Leis, M. Articles by Stamminger, T. Agricola Articles by Leis, M. Articles by Stamminger, T.

Downregulation of the cellular adhesion molecule Thy-1 (CD90) by cytomegalovirus infection of human fibroblasts

Institut für Klinische und Molekulare Virologie, Schlossgarten 4, 91054 Erlangen, Germany

Correspondence
Thomas Stamminger
thomas.stamminger{at}viro.med.uni-erlangen.de

The deregulation of cellular adhesion molecules by human cytomegalovirus (HCMV) appears to be correlated with the development of vascular disease. In this study, it was investigated whether the expression of Thy-1 (CD90), a member of the immunoglobulin superfamily of adhesion molecules with constitutive expression on fibroblast cells, is modulated following infection with HCMV. It was observed that Thy-1 cell surface expression decreased significantly during the course of infection. Addition of neutralizing antibodies, as well as UV inactivation of virus, prevented Thy-1 downregulation. In contrast, inhibition of virus replication by cidofovir did not alter Thy-1 regulation by HCMV, indicating that immediate-early (IE) and/or early (E) gene products are responsible. Interestingly, after infection of fibroblasts with a recombinant GFP-expressing virus, infected as well as non-infected cells showed a reduced Thy-1 cell surface expression. From these findings, it is concluded that IE or E gene products of HCMV induce a so far unidentified soluble factor that mediates Thy-1 downregulation.

This article has been cited by other articles:

				T. A. Rege and J. S. Hagood Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosis FASEB J, June 1, 2006; 20(8): 1045 - 1054. [Abstract] [Full Text] [PDF]

				J. S. Hagood, P. Prabhakaran, P. Kumbla, L. Salazar, M. W. MacEwen, T. H. Barker, L. A. Ortiz, T. Schoeb, G. P. Siegal, C. B. Alexander, et al. Loss of Fibroblast Thy-1 Expression Correlates with Lung Fibrogenesis Am. J. Pathol., August 1, 2005; 167(2): 365 - 379. [Abstract] [Full Text] [PDF]