J Gen Virol Try Microbiology Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 85 (2004), 2357-2364; DOI 10.1099/vir.0.80105-0

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sirén, J.
Right arrow Articles by Matikainen, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sirén, J.
Right arrow Articles by Matikainen, S.
Agricola
Right arrow Articles by Sirén, J.
Right arrow Articles by Matikainen, S.
© 2004 Society for General Microbiology

Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages

Jukka Sirén, Timo Sareneva, Jaana Pirhonen, Mari Strengell, Ville Veckman, Ilkka Julkunen and Sampsa Matikainen

Department of Microbiology, National Public Health Institute, Helsinki, Finland

Correspondence
Jukka Sirén
jukka.siren{at}ktl.fi

NK cells participate in innate immune responses by secreting gamma interferon (IFN-{gamma}) and by destroying virus-infected cells. Here the interaction between influenza A or Sendai virus-infected macrophages and NK cells has been studied. A rapid, cell–cell contact-dependent production of IFN-{gamma} from NK cells cultured with virus-infected macrophages was observed. Expression of the MHC class I-related chain B (MICB) gene, a ligand for NK cell-activating receptor NKG2D, was upregulated in virus-infected macrophages suggesting a role for MICB in the activation of the IFN-{gamma} gene in NK cells. IL12R{beta}2, IL18R and T-bet mRNA synthesis was enhanced in NK cells cultured with virus-infected macrophages. Upregulation of these genes was dependent on macrophage-derived IFN-{alpha}. In contrast to IL12R{beta}2, expression of WSX-1/TCCR, a receptor for IL27, was reduced in NK cells in response to virus-induced IFN-{alpha}. In conclusion, these results show that virus-infected macrophages activate NK cells via cytokines and direct cellular interactions and further emphasize the role of IFN-{alpha} in the activation of innate immunity.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. E. Butler, M. B. Moore, S. R. Presnell, H.-W. Chan, N. J. Chalupny, and C. T. Lutz
Proteasome Regulation of ULBP1 Transcription
J. Immunol., May 15, 2009; 182(10): 6600 - 6609.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. B. Walsh, M. B. Lodoen, R. A. Edwards, L. L. Lanier, and T. E. Lane
Evidence for Differential Roles for NKG2D Receptor Signaling in Innate Host Defense against Coronavirus-Induced Neurological and Liver Disease
J. Virol., March 15, 2008; 82(6): 3021 - 3030.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
B. R. Long, J. Michaelsson, C. P. Loo, W. M. Ballan, B.-A. N. Vu, F. M. Hecht, L. L. Lanier, J. M. Chapman, and D. F. Nixon
Elevated Frequency of Gamma Interferon-Producing NK Cells in Healthy Adults Vaccinated against Influenza Virus
Clin. Vaccine Immunol., January 1, 2008; 15(1): 120 - 130.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
R. E. Owen, E. Yamada, C. I. Thompson, L. J. Phillipson, C. Thompson, E. Taylor, M. Zambon, H. M. I. Osborn, W. S. Barclay, and P. Borrow
Alterations in Receptor Binding Properties of Recent Human Influenza H3N2 Viruses Are Associated with Reduced Natural Killer Cell Lysis of Infected Cells
J. Virol., October 15, 2007; 81(20): 11170 - 11178.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Babu, C. P. Blauvelt, and T. B. Nutman
Filarial Parasites Induce NK Cell Activation, Type 1 and Type 2 Cytokine Secretion, and Subsequent Apoptotic Cell Death
J. Immunol., August 15, 2007; 179(4): 2445 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. W. Moore, A. R. Cruz, C. J. LaVake, A. L. Marzo, C. H. Eggers, J. C. Salazar, and J. D. Radolf
Phagocytosis of Borrelia burgdorferi and Treponema pallidum Potentiates Innate Immune Activation and Induces Gamma Interferon Production
Infect. Immun., April 1, 2007; 75(4): 2046 - 2062.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
A. R. Rodriguez, B. P. Arulanandam, V. L. Hodara, H. M. McClure, E. K. Cobb, M. T. Salas, R. White, and K. K. Murthy
Influence of interleukin-15 on CD8+ natural killer cells in human immunodeficiency virus type 1-infected chimpanzees
J. Gen. Virol., February 1, 2007; 88(2): 641 - 651.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. H. Lim, S. Kireta, G. R. Russ, and P. T. H. Coates
Human plasmacytoid dendritic cells regulate immune responses to Epstein-Barr virus (EBV) infection and delay EBV-related mortality in humanized NOD-SCID mice
Blood, February 1, 2007; 109(3): 1043 - 1050.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
O. Atochina and D. Harn
LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction
Clin. Vaccine Immunol., September 1, 2005; 12(9): 1041 - 1049.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. V. Villarino, J. Larkin III, C. J. M. Saris, A. J. Caton, S. Lucas, T. Wong, F. J. de Sauvage, and C. A. Hunter
Positive and Negative Regulation of the IL-27 Receptor during Lymphoid Cell Activation
J. Immunol., June 15, 2005; 174(12): 7684 - 7691.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2004 by the Society for General Microbiology.