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Downmodulation of CD3 expression in CD8^+– T cells of feline immunodeficiency virus-infected cats

Yorihiro Nishimura^1,

Masayuki Shimojima^1,

Eiji Sato^1,

¹ Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
² Host and Defense, PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
³ Laboratory of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan

Correspondence
Takayuki Miyazawa
takavet{at}obihiro.ac.jp

Feline immunodeficiency virus (FIV) infection in cats is associated with an increase of feline CD (fCD)8^+– and fCD8^+low cells in peripheral blood. To investigate these cells in more detail, an anti-fCD3 mAb, termed NZM1, was generated, which recognizes the extracellular epitope of the fCD3 molecule. The anti-fCD3 mAb proved to be more suitable for identifying feline T cells than the anti-fCD5 one, which has been used as a pan-T-cell reagent in cats, because of the presence of fCD5⁺fCD3^– cells among lymphocytes. Although the fCD8^+– and fCD8^+low cells in the FIV-infected cats expressed fCD3, a subset of fCD8^+– cells expressed fCD3 antigen at a lower level than the T cells whose phenotype was fCD4⁺, or fCD8^+low. The lower expression of fCD3 may be associated with the immune status of fCD8^+– T cells.

Present address: Department of Virology II, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashimurayama-shi, Tokyo 208-0011, Japan.

Present address: Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo 108-8639, Japan.

Present address: Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.

||Present address: Department of Biological Chemistry, UC Davis School of Medicine, UC Davis Cancer Center, Sacramento, CA 95817, USA.

¶Present address: Food Safety Commission, The Cabinet Office, Japanese Government, Nagata-cho, Chiyoda-ku, Tokyo, Japan.

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