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Genome sequence of the non-pathogenic strain 15 of pneumonia virus of mice and comparison with the genome of the pathogenic strain J3666

L. C. Thorpe

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK

Correspondence
A. J. Easton
a.j.easton{at}warwick.ac.uk

Pneumonia virus of mice (PVM) is a member of the subfamily Pneumovirinae and is the closest known relative of respiratory syncytial virus. Both viruses cause pneumonia in their respective hosts. Here, the genome sequences of two strains of PVM, non-pathogenic strain 15 and pathogenic strain J3666, are reported. Comparison of the genome sequences revealed 59 nucleotide differences between the two strains, 37 of which were coding. The nucleotide differences were spread throughout the genome, affecting cis-acting regulatory regions and seven of the ten genes. Development of a reverse-genetics system for PVM should allow further elucidation of the functional importance of the genetic differences between the two strains identified here.

The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are AY743909 and AY743910.

Present address: Intervet UK Ltd, Walton Manor, Walton, Milton Keynes, Bucks MK7 7AJ, UK.

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