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Short Communication |
1 Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Kyrkjevegen 332-334, N-4325 Sandnes, Norway
2 Norwegian School of Veterinary Science, Department of Basic Sciences and Aquatic Medicine, PO Box 8146 Dep., N-0033 Oslo, Norway
3 National Veterinary Institute, PO Box 8156 Dep., N-0033 Oslo, Norway
4 University of Oslo, Department of Behavioural Sciences in Medicine, PO Box 1111, N-0317 Oslo, Norway
Correspondence
Truls Moum
Truls.Moum{at}veths.no
Until June 2004, thirty-eight scrapie cases with unusual features, designated Nor98, have been diagnosed in Norway. This study investigated the distribution of PrP genotypes among Nor98 cases, their flock-mates and a random sample of Norwegian slaughtered sheep. The PrP genotype distribution of Nor98 cases differed markedly from that of previous cases of classical scrapie. A leucine/phenylalanine polymorphism at codon 141 with hitherto unknown significance to scrapie was strongly associated with Nor98 cases. Twenty of 38 (52·6 %) cases were either homozygous or heterozygous for phenylalanine at codon 141. In contrast, this allele was present in only 10·5 % of the flock-mates and 4·5 % of the random sample of slaughtered sheep. Moreover, the H154 allele was represented in 24 of 38 (63·2 %) of Nor98 cases, as opposed to 27·0 % of Nor98 flock-mates and 17·0 % of the slaughtered sheep.
Published online ahead of print on 2 November as DOI 10.1099/vir.0.80437-0.
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