HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Davison, A. J. Articles by Renault, T. Search for Related Content PubMed PubMed Citation Articles by Davison, A. J. Articles by Renault, T. Agricola Articles by Davison, A. J. Articles by Renault, T.

A novel class of herpesvirus with bivalve hosts

Rose-Marie Le Deuff^4,

¹ MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
² Imaging Sciences Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA
³ Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
⁴ Laboratoire de Génétique et Pathologie, IFREMER, 17390 La Tremblade, France

Correspondence
Andrew J. Davison
a.davison{at}vir.gla.ac.uk

Ostreid herpesvirus 1 (OsHV-1) is the only member of the Herpesviridae that has an invertebrate host and is associated with sporadic mortality in the Pacific oyster (Crassostrea gigas) and other bivalve species. Cryo-electron microscopy of purified capsids revealed the distinctive T=16 icosahedral structure characteristic of herpesviruses, although the preparations examined lacked pentons. The gross genome organization of OsHV-1 was similar to that of certain mammalian herpesviruses (including herpes simplex virus and human cytomegalovirus), consisting of two invertible unique regions (U_L, 167·8 kbp; U_S, 3·4 kbp) each flanked by inverted repeats (TR_L/IR_L, 7·6 kbp; TR_S/IR_S, 9·8 kbp), with an additional unique sequence (X, 1·5 kbp) between IR_L and IR_S. Of the 124 unique genes predicted from the 207 439 bp genome sequence, 38 were members of 12 families of related genes and encoded products related to helicases, inhibitors of apoptosis, deoxyuridine triphosphatase and RING-finger proteins, in addition to membrane-associated proteins. Eight genes in three of the families appeared to be fragmented. Other genes that did not belong to the families were predicted to encode DNA polymerase, the two subunits of ribonucleotide reductase, a helicase, a primase, the ATPase subunit of terminase, a RecB-like protein, additional RING-like proteins, an ion channel and several other membrane-associated proteins. Sequence comparisons showed that OsHV-1 is at best tenuously related to the two classes of vertebrate herpesviruses (those associated with mammals, birds and reptiles, and those associated with bony fish and amphibians). OsHV-1 thus represents a third major class of the herpesviruses.

The GenBank/EMBL/DDBJ accession number of the OsHV-1 DNA sequence reported in this paper is AY509253.

SDS-PAGE analysis of the OsHV-1 capsid proteins is available as supplementary material in JGV Online.

Present address: 9 rue Traversière, 17200 St Sulpice de Royan, France.

This article has been cited by other articles:

				T. Aoki, I. Hirono, K. Kurokawa, H. Fukuda, R. Nahary, A. Eldar, A. J. Davison, T. B. Waltzek, H. Bercovier, and R. P. Hedrick Genome Sequences of Three Koi Herpesvirus Isolates Representing the Expanding Distribution of an Emerging Disease Threatening Koi and Common Carp Worldwide J. Virol., May 15, 2007; 81(10): 5058 - 5065. [Abstract] [Full Text] [PDF]

				A. J. Davison, C. Cunningham, W. Sauerbier, and R. G. McKinnell Genome sequences of two frog herpesviruses J. Gen. Virol., December 1, 2006; 87(12): 3509 - 3514. [Abstract] [Full Text] [PDF]

				M. Ilouze, A. Dishon, and M. Kotler Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi Microbiol. Mol. Biol. Rev., March 1, 2006; 70(1): 147 - 156. [Abstract] [Full Text] [PDF]

				M. L. Baker, W. Jiang, F. J. Rixon, and W. Chiu Common Ancestry of Herpesviruses and Tailed DNA Bacteriophages J. Virol., December 1, 2005; 79(23): 14967 - 14970. [Abstract] [Full Text] [PDF]

				B. G. Klupp, H. Granzow, A. Karger, and T. C. Mettenleiter Identification, Subviral Localization, and Functional Characterization of the Pseudorabies Virus UL17 Protein J. Virol., November 1, 2005; 79(21): 13442 - 13453. [Abstract] [Full Text] [PDF]

				A. J. Davison and N. D. Stow New Genes from Old: Redeployment of dUTPase by Herpesviruses J. Virol., October 15, 2005; 79(20): 12880 - 12892. [Abstract] [Full Text] [PDF]

				T. B. Waltzek, G. O. Kelley, D. M. Stone, K. Way, L. Hanson, H. Fukuda, I. Hirono, T. Aoki, A. J. Davison, and R. P. Hedrick Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae J. Gen. Virol., June 1, 2005; 86(6): 1659 - 1667. [Abstract] [Full Text] [PDF]