HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hu, J. Articles by Christensen, N. D. Search for Related Content PubMed PubMed Citation Articles by Hu, J. Articles by Christensen, N. D. Agricola Articles by Hu, J. Articles by Christensen, N. D.

Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression

¹ The Jake Gittlen Cancer Research Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
² Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
³ Department of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
⁴ Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA

Correspondence
Neil D. Christensen
ndc1{at}psu.edu

Cottontail rabbit papillomavirus (CRPV)-induced papillomas can progress into malignant carcinomas, remain persistent or regress. Both host immunity and virus genetic background play critical roles in these events. To test how host immunity influences CRPV-induced papilloma evolution, both EIII/JC (inbred) and New Zealand White (outbred) rabbits were treated with an immunosuppressive drug, cyclosporin A (CsA), for 80 days and the regression of three regressive constructs, H.CRPVr (a CRPV regressive strain), H.CRPVp-E6r (a progressive strain with regressive E6) and H.CRPVp-CE6rm (H.CRPVp with the carboxyl terminal of regressive E6, containing mutations at amino acid residues E252G, G258D and S259P) was checked. Papillomas induced by H.CRPVr and H.CRPVp-E6r on control inbred and outbred rabbits regressed totally around week 8, whereas papillomas on all CsA-treated rabbits grew progressively. After cessation of CsA treatment, papillomas began to regress in six outbred rabbits: 14 of 18 papillomas induced by CRPVr, 11 of 18 papillomas induced by H.CRPVp-E6r and eight of 10 papillomas induced by H.CRPVp-CE6rm regressed around week 21. In four CsA-treated inbred rabbits, two of 17 papillomas induced by H.CRPVr and one of 17 papillomas induced by H.CRPVp-E6r regressed. These data indicate that papillomas induced by a regressive CRPV strain can become persistent in the transiently immunosuppressed host. However, returning immunity can lead to regression and clearance of large papillomas (with increased antigenicity) in an outbred population, whilst these same antigenic papillomas persist in inbred rabbits.

This article has been cited by other articles:

				J. Hu, X. Peng, L. R. Budgeon, N. M. Cladel, K. K. Balogh, and N. D. Christensen Establishment of a Cottontail Rabbit Papillomavirus/HLA-A2.1 Transgenic Rabbit Model J. Virol., July 1, 2007; 81(13): 7171 - 7177. [Abstract] [Full Text] [PDF]

				J. Hu, X. Peng, T. D. Schell, L. R. Budgeon, N. M. Cladel, and N. D. Christensen An HLA-A2.1-Transgenic Rabbit Model to Study Immunity to Papillomavirus Infection J. Immunol., December 1, 2006; 177(11): 8037 - 8045. [Abstract] [Full Text] [PDF]