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J Gen Virol 86 (2005), 2781-2786; DOI 10.1099/vir.0.81084-0

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© 2005 Society for General Microbiology

Short Communication

Intra-host evolutionary dynamics of hepatitis C virus E2 in treated patients

Victoria Alfonso1, Viviana Andrea Mbayed1, Silvia Sookoian2 and Rodolfo Héctor Campos1

1 Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 4to piso, Buenos Aires 1113, Argentina
2 Unidad de Hepatología, Hospital Argerich, Buenos Aires, Argentina

Correspondence
Rodolfo Héctor Campos
rcampos{at}ffyb.uba.ar

Hepatitis C virus (HCV) displays high genetic diversity. Inter-host sequence variability may mainly reflect a neutral drift evolution. In contrast, intra-host evolution may be driven by an adaptive selection to host responses to infection. Here, HCV E2 intra-host evolution in two patients during the course and follow-up of successive treatments with IFN-{alpha} and IFN-{alpha}/ribavirin was investigated. Phylogenetic analyses suggested that adaptive pressures prompt a continuous selection of viral variants derived from the previous ones (intra-lineage evolution) and/or a swapping of viral lineages during the course of the infection (inter-lineage evolution). Selection would act not only on the phenotypic features of hypervariable region 1 (HVR1) but also on those of the flanking regions. The pressures operate mainly at the amino acid level, but they also appeared to act on nucleotide sequences. Moreover, HVR1 heterogeneity seemed to be strongly constrained. This work contributes to the knowledge of HCV intra-host evolution during chronicity.

The GenBank/EMBL/DDBJ accession numbers of the sequences determined in this work are AY876391–AY876493.

Supplementary material is available in JGV Online.






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