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Evolution of a rare vaccine-derived multirecombinant poliovirus

Ioannis Karakasiliotis^1,

¹ Department of Virology, Hellenic Pasteur Institute, 127 Vas. Sofias Avenue, 11521 Athens, Greece
² Department of Biochemistry and Biotechnology, University of Thessaly, 26 Ploutonos and Aiolou Street, 41221 Larissa, Greece

Correspondence
Panayotis Markoulatos
markoulatos{at}bio.uth.gr

Recombination is one of the mechanisms by which viral genomes evolve. A vaccine-derived multirecombinant poliovirus strain was isolated from a 5-month-old child with vaccine-associated paralytic poliomyelitis after oral poliovirus vaccine administration. The isolate had an S2/S1/S2/S1 primary genomic structure as revealed by restriction fragment length polymorphism and sequencing analysis. Recombination of the middle S1/S2 region is extremely rare and one of the few characterized types of recombination with Sabin type 1 as a 5' partner. An attempt was made to perform evolutionary analysis of the contributing sequences using the identified mutations in comparison with the original Sabin sequences. A hypothesis is proposed for the order in which the identified recombination events occurred.

The GenBank/EMBL/DDBJ accession numbers for the nucleotide sequences reported in this paper are AY830709–AY830710.

Present address: School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, UK.

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