J Gen Virol Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 86 (2005), 3365-3368; DOI 10.1099/vir.0.81115-0

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kraft, A. R. M.
Right arrow Articles by Dittmer, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kraft, A. R. M.
Right arrow Articles by Dittmer, U.
Agricola
Right arrow Articles by Kraft, A. R. M.
Right arrow Articles by Dittmer, U.
© 2005 Society for General Microbiology

Short Communication

Effective treatment of retrovirus-induced suppression of antibody responses with CpG oligodeoxynucleotides

Anke R. M. Kraft1, Tanja Arndt1, Kim J. Hasenkrug2 and Ulf Dittmer1

1 Institut für Virologie des Universitätsklinikums Essen, Hufelandstrasse 55, 45122 Essen, Germany
2 Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

Correspondence
Ulf Dittmer
ulf.dittmer{at}uni-essen.de

Most retroviruses induce severe immunosuppression during acute infection. We have used the Friend retrovirus mouse model to demonstrate that immunostimulatory B-type CpG oligodeoxynucleotides (ODN) have a protective effect against retrovirus-induced suppression of antibody responses to potent B-cell antigens. CD8+ T cells were critical for effective treatment with CpG-ODN, since in vivo depletion of these cells from treated mice impaired protection from retrovirus-induced immunosuppression. Protection also required IFN-{gamma}, as neutralization of this cytokine abolished the therapeutic effect of CpG-ODN. These findings may have implications for the treatment of immunosuppressive virus infections.




This article has been cited by other articles:


Home page
 BloodHome page
S. Balkow, F. Krux, K. Loser, J. U. Becker, S. Grabbe, and U. Dittmer
Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells
Blood, December 1, 2007; 110(12): 3949 - 3958.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. S. Spinner, R. B. Kascsak, G. LaFauci, H. C. Meeker, X. Ye, M. J. Flory, J. I. Kim, G. B. Schuller-Levis, W. R. Levis, T. Wisniewski, et al.
CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils
J. Leukoc. Biol., June 1, 2007; 81(6): 1374 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
S. Schneider-Schaulies and U. Dittmer
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression
J. Gen. Virol., June 1, 2006; 87(6): 1423 - 1438.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2005 by the Society for General Microbiology.