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J Gen Virol 86 (2005), 3365-3368; DOI 10.1099/vir.0.81115-0

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© 2005 Society for General Microbiology

Short Communication

Effective treatment of retrovirus-induced suppression of antibody responses with CpG oligodeoxynucleotides

Anke R. M. Kraft1, Tanja Arndt1, Kim J. Hasenkrug2 and Ulf Dittmer1

1 Institut für Virologie des Universitätsklinikums Essen, Hufelandstrasse 55, 45122 Essen, Germany
2 Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

Correspondence
Ulf Dittmer
ulf.dittmer{at}uni-essen.de

Most retroviruses induce severe immunosuppression during acute infection. We have used the Friend retrovirus mouse model to demonstrate that immunostimulatory B-type CpG oligodeoxynucleotides (ODN) have a protective effect against retrovirus-induced suppression of antibody responses to potent B-cell antigens. CD8+ T cells were critical for effective treatment with CpG-ODN, since in vivo depletion of these cells from treated mice impaired protection from retrovirus-induced immunosuppression. Protection also required IFN-{gamma}, as neutralization of this cytokine abolished the therapeutic effect of CpG-ODN. These findings may have implications for the treatment of immunosuppressive virus infections.




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