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The majority of human immunodeficiency virus type 1 particles present within splenic germinal centres are produced locally

Marie-Jeanne Dumaurier

Rémi Cheynier

Unité de Rétrovirologie Moléculaire, Institut Pasteur, Paris, France

Correspondence
Rémi Cheynier
remi{at}pasteur.fr

In most stages of human immunodeficiency virus (HIV) infection, cell-free viral particles can be detected in germinal centres (GCs) that are principally retained, in the form of immune complexes, on the surface of follicular dendritic cells (FDCs). The source of this virus remains unknown, although it is agreed that the FDCs themselves are not infected productively. By sequencing HIV viral DNA, genomic RNA and spliced mRNA isolated from individual splenic white pulps, it was shown here that the majority of HIV-1 viral particles are produced locally within the supporting lymphoid structure and do not result from trapping of circulating viruses or immune complexes. These findings underline the exquisite spatial organization of HIV-1 replication in vivo, suggesting a local origin for viruses trapped in splenic GCs.

Present address: CNRS/UNSA UMR 6097, IPMC, 660 Route des Lucioles, 06560 Valbonne, France.

Present address: Unité des Virus Lents, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France.

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