J Gen Virol
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J Gen Virol 86 (2005), 589-594; DOI 10.1099/vir.0.80623-0

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© 2005 Society for General Microbiology

Short Communication

African swine fever virus infection disrupts centrosome assembly and function

Nolwenn Jouvenet and Thomas Wileman

Department of Immunology and Pathology, Pirbright Laboratories, Institute for Animal Health, Ash Road, Woking, Surrey GU24 0NF, UK

Correspondence
Thomas Wileman
thomas.wileman{at}bbsrc.ac.uk

African swine fever virus (ASFV) is a large, enveloped DNA virus that assembles in perinuclear sites located close to the centrosome. It is reported here that the microtubule network becomes disorganized soon after the onset of viral DNA replication and formation of assembly sites. ASFV infection resulted in loss of {gamma}-tubulin and pericentrin at the centrosome; this was due to protein relocalization, but not degradation. ASFV infection also inhibited the ability of the centrosome to nucleate microtubules. The reorganization of microtubules seen in ASFV-infected cells may therefore be mediated by {gamma}-tubulin and pericentrin redistribution, and consequent disruption of centrosome assembly and function.

A figure showing the levels of expression of {gamma}-tubulin and pericentrin in ASFV-infected cells is available as supplementary material in JGV Online.




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