J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 86 (2005), 589-594; DOI 10.1099/vir.0.80623-0

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary figure
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jouvenet, N.
Right arrow Articles by Wileman, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jouvenet, N.
Right arrow Articles by Wileman, T.
Agricola
Right arrow Articles by Jouvenet, N.
Right arrow Articles by Wileman, T.
© 2005 Society for General Microbiology

Short Communication

African swine fever virus infection disrupts centrosome assembly and function

Nolwenn Jouvenet and Thomas Wileman

Department of Immunology and Pathology, Pirbright Laboratories, Institute for Animal Health, Ash Road, Woking, Surrey GU24 0NF, UK

Correspondence
Thomas Wileman
thomas.wileman{at}bbsrc.ac.uk

African swine fever virus (ASFV) is a large, enveloped DNA virus that assembles in perinuclear sites located close to the centrosome. It is reported here that the microtubule network becomes disorganized soon after the onset of viral DNA replication and formation of assembly sites. ASFV infection resulted in loss of {gamma}-tubulin and pericentrin at the centrosome; this was due to protein relocalization, but not degradation. ASFV infection also inhibited the ability of the centrosome to nucleate microtubules. The reorganization of microtubules seen in ASFV-infected cells may therefore be mediated by {gamma}-tubulin and pericentrin redistribution, and consequent disruption of centrosome assembly and function.

A figure showing the levels of expression of {gamma}-tubulin and pericentrin in ASFV-infected cells is available as supplementary material in JGV Online.




This article has been cited by other articles:


Home page
 J. Virol.Home page
M. B. Gill, J. L. Kutok, and J. D. Fingeroth
Epstein-Barr Virus Thymidine Kinase Is a Centrosomal Resident Precisely Localized to the Periphery of Centrioles
J. Virol., June 15, 2007; 81(12): 6523 - 6535.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. L. Netherton, M.-C. McCrossan, M. Denyer, S. Ponnambalam, J. Armstrong, H.-H. Takamatsu, and T. E. Wileman
African Swine Fever Virus Causes Microtubule-Dependent Dispersal of the trans-Golgi Network and Slows Delivery of Membrane Protein to the Plasma Membrane
J. Virol., November 15, 2006; 80(22): 11385 - 11392.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. C. Warren, A. Rutkowski, and L. Cassimeris
Infection with Replication-deficient Adenovirus Induces Changes in the Dynamic Instability of Host Cell Microtubules
Mol. Biol. Cell, August 1, 2006; 17(8): 3557 - 3568.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2005 by the Society for General Microbiology.