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Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae

¹ Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
² The Centre for the Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset DT4 8UB, UK
³ Department of Basic Sciences, College of Veterinary Medicine, PO Box 6100 Mississippi State, MS 39762, USA
⁴ Department of Marine Biosciences, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, Tokyo 108-8477, Japan
⁵ MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK

Correspondence
Thomas B. Waltzek
tbwaltzek{at}ucdavis.edu

The sequences of four complete genes were analysed in order to determine the relatedness of koi herpesvirus (KHV) to three fish viruses in the family Herpesviridae: carp pox herpesvirus (Cyprinid herpesvirus 1, CyHV-1), haematopoietic necrosis herpesvirus of goldfish (Cyprinid herpesvirus 2, CyHV-2) and channel catfish virus (Ictalurid herpesvirus 1, IcHV-1). The genes were predicted to encode a helicase, an intercapsomeric triplex protein, the DNA polymerase and the major capsid protein. The results showed that KHV is related closely to CyHV-1 and CyHV-2, and that the three cyprinid viruses are related, albeit more distantly, to IcHV-1. Twelve KHV isolates from four diverse geographical areas yielded identical sequences for a region of the DNA polymerase gene. These findings, with previously published morphological and biological data, indicate that KHV should join the group of related lower-vertebrate viruses in the family Herpesviridae under the formal designation Cyprinid herpesvirus 3 (CyHV-3).

The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are KHV helicase (AY939857)/triplex (AY939859), KHV DNA polymerase (AY939862) and KHV major capsid protein (AY939864); corresponding CyHV-1 sequences (AY939858, AY939860, AY939868 and AY939865, respectively); CyHV-2 sequences for parts of helicase (AY939867), triplex (AY939861) and DNA polymerase (AY939863); CyHV-1 sequence homologous to IcHV-1 ORF56 (AY939866).

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