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A novel simian immunodeficiency virus from black mangabey (Lophocebus aterrimus) in the Democratic Republic of Congo

¹ Institute for Virus Research, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
² National Institute of Biomedical Research, Kinshasa, Democratic Republic of Congo
³ Cite Louis Pasteur-Laboratoire National de Sante Publique, Brazzaville 120, Republic of Congo
⁴ Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Japan
⁵ Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Japan
⁶ Kinshasa Zoo, Kinshasa, Democratic Republic of Congo

Correspondence
Tomoyuki Miura
tmiura{at}virus.kyoto-u.ac.jp

In order to understand primate lentivirus evolution, characterization of additional simian immunodeficiency virus (SIV) strains is essential. Here, an SIV from a black mangabey (Lophocebus aterrimus) originating from the Democratic Republic of Congo was analysed phylogenetically. The monkey had cross-reactive antibodies against human immunodeficiency virus type 1 (HIV-1) and HIV-2. The viral pol region sequence was amplified by nested PCR and sequence analysis confirmed that it was related to known SIV sequences. This is the first report to characterize genetically an SIV from the monkey genus Lophocebus. Phylogenetic analysis of the pol region revealed that this novel SIV, designated SIVbkm, fell into the SIVsyk and SIVgsn virus group, containing viruses isolated from the genus Cercopithecus, and suggests that cross-species transmission has occurred between species of the genera Lophocebus and Cercopithecus.

The GenBank/EMBL/DDBJ accession number for the nucleotide sequence determined in this work is AY518534.

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