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Evidence for recombination in Crimean-Congo hemorrhagic fever virus

Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow 142782, Russia

Correspondence
Alexander N. Lukashev
Alexander_lukashev{at}hotmail.com

Crimean-Congo hemorrhagic fever (CCHF) virus has attracted considerable attention recently and a number of phylogenetic studies have been published, based mostly on partial sequences of S and M RNA segments. In this study, available full-length S, M and L segment sequences of CCHF virus were checked for recombination. Similarity plots and bootscan analysis of the S segment suggested multiple recombination events between southern European, Asian and African CCHF virus strains, with additional evidence provided by phylogenetic trees, the hidden Markov model and probabilistic divergence measures methods. No unambiguous signs of recombination were observed for M and L segments; however, the results did not exclude the possibility of this. These findings, coupled with a recent report on reassortment in CCHF virus, suggest caution when assessing CCHF virus phylogeny based on short sequence fragments.

This article has been cited by other articles:

				V. M. Deyde, M. L. Khristova, P. E. Rollin, T. G. Ksiazek, and S. T. Nichol Crimean-congo hemorrhagic Fever virus genomics and global diversity. J. Virol., September 1, 2006; 80(17): 8834 - 8842. [Abstract] [Full Text] [PDF]