HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplementary figures Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Christensen, L. S. Articles by Rosenørn, S. Search for Related Content PubMed PubMed Citation Articles by Christensen, L. S. Articles by Rosenørn, S. Agricola Articles by Christensen, L. S. Articles by Rosenørn, S.

Analysis of the epidemiological dynamics during the 1982–1983 epidemic of foot-and-mouth disease in Denmark based on molecular high-resolution strain identification

¹ Danish Institute for Food and Veterinary Research, Lindholm, DK-4771 Kalvehave, Denmark
² Risø National Laboratory, DK-4000 Roskilde, Denmark
³ Danish Meteorological Institute, Lyngbyvej 100, DK-2100 Copenhagen, Denmark

Correspondence
Laurids S. Christensen
lsi{at}dfvf.dk

An epidemic of foot-and-mouth disease (FMD) causing a total of 23 cases in 1982–1983, primarily on the island of Funen, Denmark, was subjected to molecular epidemiological investigations. In an attempt to exploit the quasi-species nature of foot-and-mouth disease virus strains for molecular high-resolution strain identification in order to analyse the dynamics of this epidemic, full-length VP1 coding regions were sequenced for 17 isolates collected at different farms during the epidemic. The sequence information together with epidemiological information gathered during the epidemic suggests that the epidemic was caused by at least three introductions across Danish borders and one case of airborne transmission between two islands in Denmark over a distance of 70 km. The assortment of nucleotide markers among the three strains is indicative of common recombination events in their evolutionary history, and the prerequisite of co- or superinfection of animals with variant strains in turn implies that they have a common source or epidemiologically related sources originating from an area with endemic FMD.

Alignment of the VP1 sequences and particle dispersion plumes from the location of the FMD outbreaks in northern Funen for a period of 6 weeks are available as supplementary material in JGV Online.

This article has been cited by other articles:

				D. Verreault, S. Moineau, and C. Duchaine Methods for Sampling of Airborne Viruses Microbiol. Mol. Biol. Rev., September 1, 2008; 72(3): 413 - 444. [Abstract] [Full Text] [PDF]

				E. M. Cottam, D. T. Haydon, D. J. Paton, J. Gloster, J. W. Wilesmith, N. P. Ferris, G. H. Hutchings, and D. P. King Molecular Epidemiology of the Foot-and-Mouth Disease Virus Outbreak in the United Kingdom in 2001 J. Virol., November 15, 2006; 80(22): 11274 - 11282. [Abstract] [Full Text] [PDF]