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Pathological prion protein in muscles of hamsters and mice infected with rodent-adapted BSE or vCJD

Achim Thomzig^1,

Franco Cardone^2,

¹ Robert Koch-Institut (P24 – Transmissible Spongiform Encephalopathies), Nordufer 20, 13353 Berlin, Germany
² Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
³ 7815 Exeter Road, Bethesda, MD 20814, USA

Correspondence
Michael Beekes
BeekesM{at}rki.de

Recently, pathological prion protein (PrP^TSE) was detected in muscle from sheep infected with scrapie, the archetype of transmissible spongiform encephalopathies (TSEs). This finding has highlighted the question of whether mammalian muscle may potentially also provide a reservoir for TSE agents related to bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–Jakob Disease (vCJD). Here, results are reported from studies in hamsters and mice that provide direct experimental evidence, for the first time, of BSE- and vCJD-associated PrP^TSE deposition in muscles. Our findings emphasize the need for further assessment of possible public-health risks from TSE involvement of skeletal muscle.

These authors contributed equally to this work.

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