HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplementary figure Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nakano, T. Articles by Pybus, O. G. Search for Related Content PubMed PubMed Citation Articles by Nakano, T. Articles by Pybus, O. G. Agricola Articles by Nakano, T. Articles by Pybus, O. G.

Population genetic history of hepatitis C virus 1b infection in China

Tatsunori Nakano^1,

Ling Lu^2,

Oliver G. Pybus^6,

¹ Department of Internal Medicine, Ichinomiya Nishi Hospital, Okucho Origuchinishi 89-1, Ichinomiya, Aichi 491-0201, Japan
² Division of Gastroenterology/Hepatology, Department of Medicine, Kansas University Medical Center, Kansas City, KS, USA
³ Da-An Diagnostic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
⁴ Guangzhou Blood Center, Guangzhou, Guangdong, China
⁵ National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
⁶ Department of Zoology, University of Oxford, Oxford, UK

Correspondence
Tatsunori Nakano
nakano{at}anzu.or.jp

Subtype 1b is the most common strain of Hepatitis C virus (HCV) in China. Here, the molecular epidemiology and epidemic history of this strain were investigated by conducting phylogenetic and population genetic analyses of E1 and NS5B gene sequences sampled from nine Chinese cities. The phylogenetic analysis indicated the presence of two clusters of Chinese strains that did not include reference strains from other countries, suggesting that these clusters represent two independent chains of HCV transmission within China. The remaining Chinese isolates were more closely related to reference strains from other countries. The date of origin and past population dynamics of the two groups were investigated using a new population genetic method, the Bayesian skyline plot. The estimated dates of origin of both groups coincide with the period of the Chinese ‘Cultural Revolution’ during the years 1966–1976. Both groups grew at a rapid exponential rate between 1970 and 1990, after which transmission slowed considerably. Possible explanations for the groups' fast spread and subsequent slowdown are discussed, including parenteral transmission by unsafe injection, iatrogenic transmission by infected blood or blood products and improvements in blood safety since 1990. These results shed light on HCV transmission in China and may help to predict the future burden of HCV-related disease in the country.

Phylogenetic trees of the concatenated sequence alignments are available as supplementary material in JGV Online.

These authors contributed equally to this work.

This article has been cited by other articles:

				O. G. Pybus, E. Barnes, R. Taggart, P. Lemey, P. V. Markov, B. Rasachak, B. Syhavong, R. Phetsouvanah, I. Sheridan, I. S. Humphreys, et al. Genetic History of Hepatitis C Virus in East Asia J. Virol., January 15, 2009; 83(2): 1071 - 1082. [Abstract] [Full Text] [PDF]