|
|
||||||||
Review article |
Institute of Virology, Medical University of Vienna, Kinderspitalgasse 15, A1095 Vienna, Austria
Correspondence
Franz X. Heinz
franz.x.heinz{at}meduniwien.ac.at
Flavivirus membrane fusion is mediated by a class II viral fusion protein, the major envelope protein E, and the fusion process is extremely fast and efficient. Understanding of the underlying mechanisms has been advanced significantly by the determination of E protein structures in their pre- and post-fusion conformations and by the elucidation of the quarternary organization of E proteins in the viral envelope. In this review, these structural data are discussed in the context of functional and biochemical analyses of the flavivirus fusion mechanism and its characteristics are compared with those of other class II- and class I-driven fusion processes.
Published online ahead of print on 5 July 2006 as DOI 10.1099/vir.0.82210-0.
This article has been cited by other articles:
![]() |
G. D. Gromowski, N. D. Barrett, and A. D. T. Barrett Characterization of Dengue Virus Complex-Specific Neutralizing Epitopes on Envelope Protein Domain III of Dengue 2 Virus J. Virol., September 1, 2008; 82(17): 8828 - 8837. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Brazzoli, A. Bianchi, S. Filippini, A. Weiner, Q. Zhu, M. Pizza, and S. Crotta CD81 Is a Central Regulator of Cellular Events Required for Hepatitis C Virus Infection of Human Hepatocytes J. Virol., September 1, 2008; 82(17): 8316 - 8329. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. G. Acosta, V. Castilla, and E. B. Damonte Functional entry of dengue virus into Aedes albopictus mosquito cells is dependent on clathrin-mediated endocytosis J. Gen. Virol., February 1, 2008; 89(2): 474 - 484. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Stiasny, S. Brandler, C. Kossl, and F. X. Heinz Probing the Flavivirus Membrane Fusion Mechanism by Using Monoclonal Antibodies J. Virol., October 15, 2007; 81(20): 11526 - 11531. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. E. Drummer, I. Boo, and P. Poumbourios Mutagenesis of a conserved fusion peptide-like motif and membrane-proximal heptad-repeat region of hepatitis C virus glycoprotein E1 J. Gen. Virol., April 1, 2007; 88(4): 1144 - 1148. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |