| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Review article |
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan
Correspondence
Yusuke Yanagi
yyanagi{at}virology.med.kyushu-u.ac.jp
Measles virus (MV), a member of the genus Morbillivirus in the family Paramyxoviridae, is an enveloped virus with a non-segmented, negative-strand RNA genome. It has two envelope glycoproteins, the haemagglutinin (H) and fusion proteins, which are responsible for attachment and membrane fusion, respectively. Human signalling lymphocyte activation molecule (SLAM; also called CD150), a membrane glycoprotein of the immunoglobulin superfamily, acts as a cellular receptor for MV. SLAM is expressed on immature thymocytes, activated lymphocytes, macrophages and dendritic cells and regulates production of interleukin (IL)-4 and IL-13 by CD4+ T cells, as well as production of IL-12, tumour necrosis factor alpha and nitric oxide by macrophages. The distribution of SLAM is in accord with the lymphotropism and immunosuppressive nature of MV. Canine distemper virus and Rinderpest virus, other members of the genus Morbillivirus, also use canine and bovine SLAM as receptors, respectively. Laboratory-adapted MV strains may use the ubiquitously expressed CD46, a complement-regulatory molecule, as an alternative receptor through amino acid substitutions in the H protein. Furthermore, MV can infect SLAM– cells, albeit inefficiently, via the SLAM- and CD46-independent pathway, which may account for MV infection of epithelial, endothelial and neuronal cells in vivo. MV infection, however, is not determined entirely by the H protein–receptor interaction, and other MV proteins can also contribute to its efficient growth by facilitating virus replication at post-entry steps. Identification of SLAM as the principal receptor for MV has provided us with an important clue for better understanding of MV tropism and pathogenesis.
Published online ahead of print on 22 June 2006 as DOI 10.1099/vir.0.82221-0.
This article has been cited by other articles:
|
|
 |
|
  M. Tahara, M. Takeda, Y. Shirogane, T. Hashiguchi, S. Ohno, and Y. Yanagi Measles Virus Infects both Polarized Epithelial and Immune Cells by Using Distinctive Receptor-Binding Sites on Its Hemagglutinin J. Virol., May 1, 2008; 82(9): 4630 - 4637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Runkler, E. Dietzel, M. Moll, H.-D. Klenk, and A. Maisner Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes J. Gen. Virol., March 1, 2008; 89(3): 687 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hashiguchi, M. Kajikawa, N. Maita, M. Takeda, K. Kuroki, K. Sasaki, D. Kohda, Y. Yanagi, and K. Maenaka Crystal structure of measles virus hemagglutinin provides insight into effective vaccines PNAS, December 4, 2007; 104(49): 19535 - 19540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takeda, M. Tahara, T. Hashiguchi, T. A. Sato, F. Jinnouchi, S. Ueki, S. Ohno, and Y. Yanagi A Human Lung Carcinoma Cell Line Supports Efficient Measles Virus Growth and Syncytium Formation via a SLAM- and CD46-Independent Mechanism J. Virol., November 1, 2007; 81(21): 12091 - 12096. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shingai, T. Ebihara, N. A. Begum, A. Kato, T. Honma, K. Matsumoto, H. Saito, H. Ogura, M. Matsumoto, and T. Seya Differential Type I IFN-Inducing Abilities of Wild-Type versus Vaccine Strains of Measles Virus J. Immunol., November 1, 2007; 179(9): 6123 - 6133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tahara, M. Takeda, and Y. Yanagi Altered Interaction of the Matrix Protein with the Cytoplasmic Tail of Hemagglutinin Modulates Measles Virus Growth by Affecting Virus Assembly and Cell-Cell Fusion J. Virol., July 1, 2007; 81(13): 6827 - 6836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tahara, M. Takeda, F. Seki, T. Hashiguchi, and Y. Yanagi Multiple Amino Acid Substitutions in Hemagglutinin Are Necessary for Wild-Type Measles Virus To Acquire the Ability To Use Receptor CD46 Efficiently J. Virol., March 15, 2007; 81(6): 2564 - 2572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ohno, N. Ono, F. Seki, M. Takeda, S. Kura, T. Tsuzuki, and Y. Yanagi Measles Virus Infection of SLAM (CD150) Knockin Mice Reproduces Tropism and Immunosuppression in Human Infection J. Virol., February 15, 2007; 81(4): 1650 - 1659. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
