HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ren, W. Articles by Shi, Z. Search for Related Content PubMed PubMed Citation Articles by Ren, W. Articles by Shi, Z. Agricola Articles by Ren, W. Articles by Shi, Z.

Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis

¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences (CAS), Wuhan, Hubei 430071, China
² Graduate School of CAS, Beijing 100039, China
³ Institute of Zoology, CAS, Beijing 100080, China
⁴ CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia
⁵ Shanghai Center for Bioinformation Technology, Shanghai 200235, China
⁶ School of Life Sciences, Fudan University, Shanghai 200433, China

Correspondence
Zhengli Shi
zlshi{at}wh.iov.cn

Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88–92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.

This article has been cited by other articles:

				C.-C. Hon, T.-Y. Lam, Z.-L. Shi, A. J. Drummond, C.-W. Yip, F. Zeng, P.-Y. Lam, and F. C.-C. Leung Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus J. Virol., February 15, 2008; 82(4): 1819 - 1826. [Abstract] [Full Text] [PDF]

				W. Ren, X. Qu, W. Li, Z. Han, M. Yu, P. Zhou, S.-Y. Zhang, L.-F. Wang, H. Deng, and Z. Shi Difference in Receptor Usage between Severe Acute Respiratory Syndrome (SARS) Coronavirus and SARS-Like Coronavirus of Bat Origin J. Virol., February 15, 2008; 82(4): 1899 - 1907. [Abstract] [Full Text] [PDF]

				V. C. C. Cheng, S. K. P. Lau, P. C. Y. Woo, and K. Y. Yuen Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection Clin. Microbiol. Rev., October 1, 2007; 20(4): 660 - 694. [Abstract] [Full Text] [PDF]

				A. Ackermann, P. Staeheli, and U. Schneider Adaptation of Borna Disease Virus to New Host Species Attributed to Altered Regulation of Viral Polymerase Activity J. Virol., August 1, 2007; 81(15): 7933 - 7940. [Abstract] [Full Text] [PDF]