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J Gen Virol 87 (2006), 277-285; DOI 10.1099/vir.0.81551-0

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© 2006 Society for General Microbiology

Human herpesvirus 6 envelope cholesterol is required for virus entry

Honglan Huang1, Yongmei Li1, Tomohiko Sadaoka2, Huanmin Tang2, Takahito Yamamoto3, Koichi Yamanishi1,2 and Yasuko Mori1,2

1 Department of Microbiology, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan
2 Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan
3 The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-Cho, Kanonji, Kagawa 768-0061, Japan

Correspondence
Yasuko Mori
ymori{at}nibio.go.jp

In this study, the role of cholesterol in the envelope of human herpesvirus 6 (HHV-6) was examined by using methyl-beta-cyclodextrin (MbetaCD) depletion. When cholesterol was removed from HHV-6 virions with MbetaCD, infectivity was abolished, but it could be rescued by the addition of exogenous cholesterol. HHV-6 binding was affected slightly by MbetaCD treatment. In contrast, envelope cholesterol depletion markedly affected HHV-6 infectivity and HHV-6-induced cell fusion. These results suggest that the cholesterol present in the HHV-6 envelope plays a prominent role in the fusion process and is a key component in viral entry.




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