HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Natoni, A. Articles by Roberts, L. O. Search for Related Content PubMed PubMed Citation Articles by Natoni, A. Articles by Roberts, L. O. Agricola Articles by Natoni, A. Articles by Roberts, L. O.

The mitochondrial pathway of apoptosis is triggered during feline calicivirus infection

School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK

Correspondence
Lisa O. Roberts
l.roberts{at}surrey.ac.uk

Feline calicivirus (FCV) belongs to the family Caliciviridae and is an important pathogen of the upper respiratory tract of cats. Recent studies have shown that cells infected with FCV undergo apoptosis, as evidenced by caspase activation, chromatin condensation and cleavage of poly(ADP-ribose) polymerase. Here, the upstream events were investigated in order to define the molecular mechanism of apoptosis in FCV-infected cells. It was shown that FCV induced translocation of phosphatidylserine to the cell outer membrane and release of cytochrome c from mitochondria at about 6–8 h post-infection. These events were preceded by the loss of mitochondrial membrane potential and Bax translocation from the cytosol to mitochondria between 4 and 6 h after infection. Release of cytochrome c from mitochondria triggered the activation of caspase-9 and the subsequent activation of the executioner caspase, caspase-3. These results suggest that the mitochondrial pathway of apoptosis is triggered during FCV infection.

This article has been cited by other articles:

				K. Bok, V. G. Prikhodko, K. Y. Green, and S. V. Sosnovtsev Apoptosis in Murine Norovirus-Infected RAW264.7 Cells Is Associated with Downregulation of Survivin J. Virol., April 15, 2009; 83(8): 3647 - 3656. [Abstract] [Full Text] [PDF]

				S. Martin-Latil, L. Mousson, A. Autret, F. Colbere-Garapin, and B. Blondel Bax Is Activated during Rotavirus-Induced Apoptosis through the Mitochondrial Pathway J. Virol., May 1, 2007; 81(9): 4457 - 4464. [Abstract] [Full Text] [PDF]

				R. J. Ossiboff, A. Sheh, J. Shotton, P. A. Pesavento, and J. S. L. Parker Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates J. Gen. Virol., February 1, 2007; 88(2): 506 - 517. [Abstract] [Full Text] [PDF]