J Gen Virol Try IJSEM Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 87 (2006), 501-508; DOI 10.1099/vir.0.81374-0

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sadaoka, T.
Right arrow Articles by Mori, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sadaoka, T.
Right arrow Articles by Mori, Y.
Agricola
Right arrow Articles by Sadaoka, T.
Right arrow Articles by Mori, Y.
© 2006 Society for General Microbiology

Human herpesvirus 7 U47 gene products are glycoproteins expressed in virions and associate with glycoprotein H

Tomohiko Sadaoka, Koichi Yamanishi and Yasuko Mori

Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8, Saito-Asagi, Ibaraki, Osaka 567-0085, Japan

Correspondence
Yasuko Mori
ymori{at}nibio.go.jp

The function of the human herpesvirus 7 (HHV-7) U47 gene, which is a positional homologue of the genes encoding glycoprotein O (gO) in human cytomegalovirus (HCMV) and human herpesvirus 6 (HHV-6), was analysed. A monoclonal antibody (mAb) against the U47 gene product reacted in immunoblots with proteins migrating at 49 and 51 kDa in lysates of HHV-7-infected cells and with 49 and 51 kDa proteins in partially purified virions. Digestion of the 49 and 51 kDa proteins with endoglycosidase H and peptide N-glycosidase F indicated that the U47-encoded proteins were modified with N-linked oligosaccharides. Therefore, the U47 gene and its product were named gO, as in HCMV and HHV-6. In addition, the anti-gO mAb co-immunoprecipitated glycoprotein H (gH) in HHV-7-infected cells, indicating an association between HHV-7 gO and gH. The results suggest that the HHV-7 gO–gH complex might have a similar function to that in HCMV or HHV-6, such as cell–cell fusion in virus infection.




This article has been cited by other articles:


Home page
 J. Virol.Home page
X. J. Jiang, B. Adler, K. L. Sampaio, M. Digel, G. Jahn, N. Ettischer, Y.-D. Stierhof, L. Scrivano, U. Koszinowski, M. Mach, et al.
UL74 of Human Cytomegalovirus Contributes to Virus Release by Promoting Secondary Envelopment of Virions
J. Virol., March 15, 2008; 82(6): 2802 - 2812.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Sadaoka, H. Yoshii, T. Imazawa, K. Yamanishi, and Y. Mori
Deletion in Open Reading Frame 49 of Varicella-Zoster Virus Reduces Virus Growth in Human Malignant Melanoma Cells but Not in Human Embryonic Fibroblasts
J. Virol., November 15, 2007; 81(22): 12654 - 12665.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
M. Takemoto, K. Yamanishi, and Y. Mori
Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells
J. Gen. Virol., May 1, 2007; 88(5): 1415 - 1422.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2006 by the Society for General Microbiology.