HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Andréoletti, O. Articles by Lantier, F. Search for Related Content PubMed PubMed Citation Articles by Andréoletti, O. Articles by Lantier, F. Agricola Articles by Andréoletti, O. Articles by Lantier, F.

Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep

¹ UMR INRA ENVT 1225, Interactions Hôte-Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France
² CEA, Service de Pharmacologie et d'Immunologie, CEA/Saclay, 91191 Gif sur Yvette cedex, France
³ INRA, Pathologie Infectieuse et Immunologie, INRA Nouzilly, 37380 Nouzilly, France
⁴ CISA, Instituto National de Investigacion y Tecnologia Agraria y Alimentaria, 28130 Valdeolmos, Spain

Correspondence
Olivier Andréoletti
o.andreoletti{at}envt.fr

Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrP^Sc in the spleen.

This article has been cited by other articles:

				G. C. Saunders, I. Lantier, S. Cawthraw, P. Berthon, S. J. Moore, M. E. Arnold, O. Windl, M. M. Simmons, O. Andreoletti, S. Bellworthy, et al. Protective effect of the T112 PrP variant in sheep challenged with bovine spongiform encephalopathy J. Gen. Virol., October 1, 2009; 90(10): 2569 - 2574. [Abstract] [Full Text] [PDF]

				P. Sarradin, S. Melo, C. Barc, C. Lecomte, O. Andreoletti, F. Lantier, J.-L. Dacheux, and J.-L. Gatti Semen from scrapie-infected rams does not transmit prion infection to transgenic mice Reproduction, March 1, 2008; 135(3): 415 - 418. [Abstract] [Full Text] [PDF]

				H. R Fryer, M. Baylis, K. Sivam, and A. R McLean Quantifying the risk from ovine BSE and the impact of control strategies Proc R Soc B, June 22, 2007; 274(1617): 1497 - 1503. [Abstract] [Full Text] [PDF]

				J. C. Espinosa, M. Morales, J. Castilla, M. Rogers, and J. M. Torres Progression of prion infectivity in asymptomatic cattle after oral bovine spongiform encephalopathy challenge J. Gen. Virol., April 1, 2007; 88(4): 1379 - 1383. [Abstract] [Full Text] [PDF]