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J Gen Virol 87 (2006), 803-807; DOI 10.1099/vir.0.81577-0

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© 2006 Society for General Microbiology

Short Communication

The M4 gene of murine gammaherpesvirus 68 modulates latent infection

Hannah M. Geere1, Yvonne Ligertwood1, Kerra M. Templeton1, Ian Bennet1, Babunilayam Gangadharan1, Susan M. Rhind2, Anthony A. Nash1 and Bernadette M. Dutia1

1 Centre for Infectious Diseases, Division of Veterinary Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
2 Division of Animal Health and Welfare, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian EH25 9RG, UK

Correspondence
Bernadette M. Dutia
B.M.Dutia{at}ed.ac.uk

Murine gammaherpesvirus 68 (MHV-68) encodes a set of unique genes, M1, M2, M3 and M4, and eight non-translated tRNA-like molecules that are thought to be important in virus–host interactions and latent infection. The M4 gene is predicted to encode a novel secreted protein. To investigate the role of M4 in viral pathogenesis, a mutant MHV-68 that did not express M4 was constructed and its replication was characterized in vitro and in vivo. Virus replication was identical to the wild type in vitro and no difference could be detected in virus replication in the lung following intranasal infection. However, in the spleen, virus deficient in M4 expression was severely attenuated in the establishment of latency. These results indicate a critical role for M4 in MHV-68 pathogenesis.




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[Abstract] [Full Text] [PDF]


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