HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jacobs, N. Articles by Smith, G. L. Search for Related Content PubMed PubMed Citation Articles by Jacobs, N. Articles by Smith, G. L. Agricola Articles by Jacobs, N. Articles by Smith, G. L.

Intradermal immune response after infection with Vaccinia virus

Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK

Correspondence
Geoffrey L. Smith
glsmith{at}imperial.ac.uk

Although Vaccinia virus (VACV) was used to eradicate smallpox by dermal vaccination, there is little information available about the immune response induced at the vaccination site. Previously, an intradermal murine model that mimics smallpox vaccination was established. Here, this model was used to investigate which leukocytes are recruited to the infected lesion and what are the kinetics of recruitment. Data presented show that VACV infection induced the infiltration of macrophages, followed by granulocytes and lymphocytes. Up to 4 days post-infection, the major lymphocyte population was TCR T cells, but thereafter, there was a large recruitment of CD4⁺ and CD8⁺ T cells. Interestingly, the majority of T cells expressed the natural killer-cell marker DX5. This report is the first to characterize the local immune response sequence to VACV infection and represents a benchmark against which the responses induced by genetically modified VACVs may be compared.

This article has been cited by other articles:

				M. Trilling, V. T. K. Le, A. Zimmermann, H. Ludwig, K. Pfeffer, G. Sutter, G. L. Smith, and H. Hengel Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts J. Virol., April 15, 2009; 83(8): 3684 - 3695. [Abstract] [Full Text] [PDF]

				R. Rahbar, T. T. Murooka, and E. N. Fish Role for CCR5 in Dissemination of Vaccinia Virus In Vivo J. Virol., March 1, 2009; 83(5): 2226 - 2236. [Abstract] [Full Text] [PDF]

				N. Jacobs, N. W. Bartlett, R. H. Clark, and G. L. Smith Vaccinia virus lacking the Bcl-2-like protein N1 induces a stronger natural killer cell response to infection J. Gen. Virol., November 1, 2008; 89(11): 2877 - 2881. [Abstract] [Full Text] [PDF]

				A. S. Fahy, R. H. Clark, E. F. Glyde, and G. L. Smith Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence J. Gen. Virol., October 1, 2008; 89(10): 2377 - 2387. [Abstract] [Full Text] [PDF]

				P. Singh, Y. Yao, A. Weliver, H. E. Broxmeyer, S.-C. Hong, and C.-H. Chang Vaccinia Virus Infection Modulates the Hematopoietic Cell Compartments in the Bone Marrow Stem Cells, April 1, 2008; 26(4): 1009 - 1016. [Abstract] [Full Text] [PDF]

				G. C. Froggatt, G. L. Smith, and P. M. Beard Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response J. Gen. Virol., July 1, 2007; 88(7): 1917 - 1921. [Abstract] [Full Text] [PDF]

				R. A.-J. Chen, N. Jacobs, and G. L. Smith Vaccinia virus strain Western Reserve protein B14 is an intracellular virulence factor J. Gen. Virol., June 1, 2006; 87(6): 1451 - 1458. [Abstract] [Full Text] [PDF]