HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Winter, C. Articles by Herrler, G. Search for Related Content PubMed PubMed Citation Articles by Winter, C. Articles by Herrler, G. Agricola Articles by Winter, C. Articles by Herrler, G.

Sialic acid is a receptor determinant for infection of cells by avian Infectious bronchitis virus

¹ Institute for Virology and Clinic for Poultry, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany
² Institute for Animal Health, Division of Microbiology, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, UK

Correspondence
Georg Herrler
Georg.Herrler{at}tiho-hannover.de

The importance of sialic acid for infection by avian Infectious bronchitis virus (IBV) has been analysed. Neuraminidase treatment rendered Vero, baby hamster kidney and primary chicken kidney cells resistant to infection by the IBV-Beaudette strain. Sialic acid-dependent infection was also observed with strain M41 of IBV, which infects primary chicken kidney cells but not cells from other species. In comparison with Influenza A virus and Sendai virus, IBV was most sensitive to pre-treatment of cells with neuraminidase. This finding suggests that IBV requires a greater amount of sialic acid on the cell surface to initiate an infection compared with the other two viruses. In previous studies, with respect to the haemagglutinating activity of IBV, it has been shown that the virus preferentially recognizes 2,3-linked sialic acid. In agreement with this finding, susceptibility to infection by IBV was connected to the expression of 2,3-linked sialic acid as indicated by the reactivity with the lectin Maackia amurensis agglutinin. Here, it is discussed that binding to sialic acid may be used by IBV for primary attachment to the cell surface; tighter binding and subsequent fusion between the viral and the cellular membrane may require interaction with a second receptor.

This article has been cited by other articles:

				C. Winter, C. Schwegmann-Wessels, U. Neumann, and G. Herrler The Spike Protein of Infectious Bronchitis Virus Is Retained Intracellularly by a Tyrosine Motif J. Virol., March 15, 2008; 82(6): 2765 - 2771. [Abstract] [Full Text] [PDF]

				J. R. Teuton and C. R. Brandt Sialic Acid on Herpes Simplex Virus Type 1 Envelope Glycoproteins Is Required for Efficient Infection of Cells J. Virol., April 15, 2007; 81(8): 3731 - 3739. [Abstract] [Full Text] [PDF]

				H. Imhoff, V. von Messling, G. Herrler, and L. Haas Canine Distemper Virus Infection Requires Cholesterol in the Viral Envelope J. Virol., April 15, 2007; 81(8): 4158 - 4165. [Abstract] [Full Text] [PDF]

				A. D. Stuart and T. D. K. Brown {alpha}2,6-Linked sialic acid acts as a receptor for Feline calicivirus J. Gen. Virol., January 1, 2007; 88(1): 177 - 186. [Abstract] [Full Text] [PDF]