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Analysis of gene-expression profiles by oligonucleotide microarray in children with influenza

Hiroshi Kimura^1,

¹ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
² Department of Pediatrics, Nagoya Ekisaikai Hospital, Nagoya, Japan
³ Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
⁴ Development Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University, Toyoake, Japan
⁵ Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

Correspondence
Hiroshi Kimura
hkimura{at}med.nagoya-u.ac.jp

In order to clarify the mechanism of the host response to influenza virus, gene-expression profiles of peripheral blood obtained from paediatric patients with influenza were investigated by oligonucleotide microarray. In the acute phase of influenza, 200 genes were upregulated and 20 genes were downregulated compared with their expression in the convalescent phase. Interferon-regulated genes, such as interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) and vipirin, were strongly upregulated in the acute phase. Gene ontology analysis showed that immune response genes were highly overrepresented among the upregulated genes. Gene-expression profiles of influenza patients with and without febrile convulsion were also studied. In patients with febrile convulsion, 22 genes were upregulated and five were downregulated compared with their expression in patients without febrile convulsion. These results should help to clarify the pathogenesis of influenza and its neurological complications.

Details of genes up- and downregulated during the acute phase of infection are available as supplementary material in JGV Online.

Present address: Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

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