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J Gen Virol 87 (2006), 1835-1841; DOI 10.1099/vir.0.81782-0

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© 2006 Society for General Microbiology

Short Communication

Porcine reproductive and respiratory syndrome virus strains of exceptional diversity in eastern Europe support the definition of new genetic subtypes

T. Stadejek1, M. B. Oleksiewicz2, D. Potapchuk3 and K. Podgórska1

1 National Veterinary Research Institute, Al. Partyzantów 57, 24-100 Pulawy, Poland
2 Novo Nordisk A/S, Virology and Molecular Toxicology, Novo Nordisk Park, 2760 Måløv, Denmark
3 S. N. Vyshelesskij Institute of Experimental Veterinary Medicine, National Academy of Sciences of Belarus, 2 Vyshelesskij Street, Minsk 223020, Belarus

Correspondence
T. Stadejek
stadejek{at}piwet.pulawy.pl

Porcine reproductive and respiratory syndrome virus (PRRSV) ORF5 and ORF7 sequences from Belarus were found to be of the European (EU) genotype, but grouped separately from all other EU genotype sequences described so far, including live-attenuated EU genotype PRRSV vaccines and Italian EU genotype sequences, some of which have been associated with reduced vaccine efficacy. Also, the Belarusian EU-PRRSV exhibited extreme ORF7 size polymorphism, ranging from 375 nt (the smallest EU genotype ORF7 yet described) to 393 nt (the largest ORF7 yet described for any arterivirus). With the Belarusian sequences, the diversity of EU genotype PRRSV now exceeds that of the North American (US) genotype PRRSV, suggesting a European origin of PRRSV. Finally, a very sharp geographical demarcation of highly diverse EU genotype PRRSV was observed along the eastern Polish border. The new Belarusian sequences have relevance for vaccine and diagnostic-antigen design and show that sequence analysis of PRRSV from more eastern parts of Europe may offer further insights into the emergence and evolution of PRRSV.

Published online ahead of print on 7 April 2006 as DOI 10.1099/vir.0.81782-0.

Supplementary figures and a table showing details of the Belarusian and Polish herds from which sequences were obtained are available in JGV Online.






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