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1'S-1'-Acetoxychavicol acetate isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 replication by blocking Rev transport

Ying Ye^1,2,

¹ Department of Research and Development, Nanchang Helioeast Science and Technology Co. Ltd, Nanchang, Jiangxi 330096, People's Republic of China
² Department of Biomedical Sciences and the Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, People's Republic of China

Correspondence
Baoan Li
bali{at}xmu.edu.cn

AIDS remains a major global health concern. Despite a number of therapeutic advancements, there is still an urgent need to develop a new class of therapy for human immunodeficiency virus (HIV). Here, it was shown that 1'S-1'-acetoxychavicol acetate (ACA), a small molecular compound isolated from the rhizomes of Alpinia galanga, inhibited Rev transport at a low concentration by binding to chromosomal region maintenance 1 and accumulating full-length HIV-1 RNA in the nucleus, resulting in a block in HIV-1 replication in peripheral blood mononuclear cells. Additionally, ACA and didanosine acted synergistically to inhibit HIV-1 replication. Thus, ACA may represent a novel treatment for HIV-1 infection, especially in combination with other anti-HIV drugs.

Present address: University of California, Irvine, CA 92697, USA.

This article has been cited by other articles:

				H. C. T. Groom, E. C. Anderson, and A. M. L. Lever Rev: beyond nuclear export J. Gen. Virol., June 1, 2009; 90(6): 1303 - 1318. [Abstract] [Full Text] [PDF]

				H. C. T. Groom, E. C. Anderson, J. A. Dangerfield, and A. M. L. Lever Rev regulates translation of human immunodeficiency virus type 1 RNAs J. Gen. Virol., May 1, 2009; 90(5): 1141 - 1147. [Abstract] [Full Text] [PDF]