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Proteome alterations in human host cells infected with coxsackievirus B3

Alexander Rassmann^1,

Thomas Munder^1,

¹ Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany
² Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans-Knoell-Strasse 2, D-07745 Jena, Germany
³ Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany
⁴ Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute Beutenbergstrasse 11a, D-07745 Jena, Germany

Correspondence
Thomas Munder
thomas.munder{at}hki-jena.de

Coxsackievirus B3 (CVB3) is a common factor in human myocarditis. The interplay between host factors and virus components is crucial for the fate of the infected cells. Despite that, host protein responses, which characterize CVB3-induced diseases, have not yet been determined in detail. To investigate the nature of modified protein patterns in infected human cells compared with uninfected cells, two-dimensional gel electrophoresis in combination with matrix-assisted laser desorption/ionization-mass spectrometry were used. The regulated proteins, e.g. nucleophosmin (nucleolar protein B23), lamin, the RNA-binding protein UNR and the p38 mitogen-activated protein kinase, were sorted according to their functional groups and interpreted in the context of the myocarditis process.

A supplementary table showing the differentially regulated or modified proteins detected upon CVB3 infection of human HeLa and HepG2 cells is available in JGV Online.

Present address: MEDLAB Gotha-Laborpraxis Bösenberg, Schützenberg 10, D-99867 Gotha, Germany.

Present address: CLONDIAG Chip Technologies GmbH, Löbstedter Straße 103-105, D-07749 Jena, Germany.

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