J Gen Virol Faster Access
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 88 (2007), 143-147; DOI 10.1099/vir.0.82263-0

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gao, F.
Right arrow Articles by Margolis, H. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gao, F.
Right arrow Articles by Margolis, H. S.
Agricola
Right arrow Articles by Gao, F.
Right arrow Articles by Margolis, H. S.
© 2007 Society for General Microbiology

Short Communication

Recombinant hepatitis C virus in experimentally infected chimpanzees

Fengxiang Gao{ddagger}, Omana V. Nainan{dagger}, Yuri Khudyakov, Jinfeng Li, Ying Hong, Aileen Co Gonzales, John Spelbring and Harold S. Margolis§

Division of Viral Hepatitis, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, USA

Correspondence
Fengxiang Gao
Fgao{at}dhhs.state.nh.us

Genetic recombination between different strains of Hepatitis C virus (HCV) was investigated in three chimpanzees inoculated experimentally with factor VIII concentrate containing HCV subgenotypes 1a, 1b, 2b and 3a. A 750 bp long fragment from the HCV envelope region was amplified by RT-PCR and quasispecies were isolated by plasmid cloning. Nucleotide sequences derived from isolated quasispecies were screened for the presence of inter-subgenotypic recombination by using sequence analysis. Recombination between HCV subgenotype 1a and 1b was found in two animals; each recombinant variant differed by location of predicted crossover region or order of subgenotype 1a and 1b sequences.

{dagger}Deceased 3 September 2005.

{ddagger}Present address: Public Health Laboratories, New Hampshire State Department of Health and Human Service, 29 Hazen Drive, Concord, NH 03301, USA.

§Present address: International Vaccine Institute, Seoul, Korea.




This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
J. Aaskov, K. Buzacott, E. Field, K. Lowry, A. Berlioz-Arthaud, and E. C. Holmes
Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient
J. Gen. Virol., December 1, 2007; 88(12): 3334 - 3340.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2007 by the Society for General Microbiology.