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Comparison of ovine herpesvirus 2 genomes isolated from domestic sheep (Ovis aries) and a clinically affected cow (Bos bovis)

¹ Animal Disease Research Unit, USDA-Agricultural Research Service, Washington State University, PO Box 646630, Pullman, WA 99164-6630, USA
² Division of Medical Microbiology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
³ Institute of Virology, University of Zurich, Zurich, Switzerland
⁴ US Sheep Experiment Station, USDA-Agricultural Research Service, Dubois, ID, USA
⁵ Program in Vector-borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA

Correspondence
Naomi S. Taus
tausns{at}vetmed.wsu.edu

The rhadinovirus Ovine herpesvirus 2 (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever. OvHV-2 primarily affects ruminants and has a worldwide distribution. In this study, a composite sequence of OvHV-2 genomic DNA isolated from nasal secretions of sheep experiencing virus-shedding episodes was determined and compared with the sequence of OvHV-2 DNA isolated from a lymphoblastoid cell line derived from a clinically affected cow. The study confirmed the OvHV-2 sequence information determined for the cell line-isolated DNA and showed no apparently significant changes in the OvHV-2 genome during passage through a clinically susceptible species with subsequent maintenance in vitro. Amino acid identity between the predicted open reading frames (ORFs) of the two genomes was 94–100 %, except for ORF73, which had an identity of 83 %. Polymorphism in ORF73 was due primarily to variability in the G/E-rich repetitive central region of the ORF.

The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are DQ198083, DQ218141 and DQ218142.

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