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Full-length genome sequences of hepatitis C virus subtype 4f

¹ Service de Virologie, CHU de Toulouse, Institut Fédératif de Biologie, F-31059 Toulouse, France
² INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, F-31300 Toulouse, France
³ Facultés de Médecine et de Pharmacie, Université Toulouse III Paul-Sabatier, F-31400 Toulouse, France
⁴ Laboratoire de Virologie, Centre Pasteur du Cameroun, Cameroon

Correspondence
Christophe Pasquier
pasquier.c{at}chu-toulouse.fr

Hepatitis C virus genotype 4 (HCV-4) is very common in central Africa, prevalent in the Middle East, and is becoming increasingly frequent among southern Europeans. We have determined the complete nucleotide sequences of HCV-4f strains and investigated their phylogenetic relationships with other genotypes. We amplified the complete genome of two HCV subtype 4f strains, IFBT84 and IFBT88. The HCV-4f strains have a total of 9181 and 9304 nt, respectively, including the 5' untranslated region followed by a single open reading frame. There was no evidence of genomic recombination in the IFBT84 and IFBT88 strains. The sequences of the HCV-4f strain genomes are closer to those of HCV-1b than to genotypes 2, 3, 5 and 6. It is important to know the full-length sequences of HCV-4 subtypes in order to classify them correctly and to obtain more detailed knowledge about HCV epidemiology and sensitivity to interferon.

The GenBank/EMBL/DDBJ accession numbers for sequences reported in this paper are EF589160 and EF589161.

Sequence of the primers used in this study is available with the online version of this paper.

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