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J Gen Virol 88 (2007), 2985-2990; DOI 10.1099/vir.0.83151-0

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Short Communication

Full-length genome sequences of hepatitis C virus subtype 4f

Fatma Hmaied1,3, Florence Legrand-Abravanel1,2,3, Florence Nicot1,2,3, Natalie Garrigues3, Sabine Chapuy-Regaud1,2,3, Martine Dubois1,2, Richard Njouom1,3,4, Jacques Izopet1,2,3 and Christophe Pasquier1,2,3

1 Service de Virologie, CHU de Toulouse, Institut Fédératif de Biologie, F-31059 Toulouse, France
2 INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, F-31300 Toulouse, France
3 Facultés de Médecine et de Pharmacie, Université Toulouse III Paul-Sabatier, F-31400 Toulouse, France
4 Laboratoire de Virologie, Centre Pasteur du Cameroun, Cameroon

Correspondence
Christophe Pasquier
pasquier.c{at}chu-toulouse.fr

Hepatitis C virus genotype 4 (HCV-4) is very common in central Africa, prevalent in the Middle East, and is becoming increasingly frequent among southern Europeans. We have determined the complete nucleotide sequences of HCV-4f strains and investigated their phylogenetic relationships with other genotypes. We amplified the complete genome of two HCV subtype 4f strains, IFBT84 and IFBT88. The HCV-4f strains have a total of 9181 and 9304 nt, respectively, including the 5' untranslated region followed by a single open reading frame. There was no evidence of genomic recombination in the IFBT84 and IFBT88 strains. The sequences of the HCV-4f strain genomes are closer to those of HCV-1b than to genotypes 2, 3, 5 and 6. It is important to know the full-length sequences of HCV-4 subtypes in order to classify them correctly and to obtain more detailed knowledge about HCV epidemiology and sensitivity to interferon.

The GenBank/EMBL/DDBJ accession numbers for sequences reported in this paper are EF589160 and EF589161.

Sequence of the primers used in this study is available with the online version of this paper.






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Copyright © 2007 by the Society for General Microbiology.