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J Gen Virol 88 (2007), 3007-3012; DOI 10.1099/vir.0.83042-0

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Short Communication

Classical swine fever virus inhibits nitric oxide production in infected macrophages

K. M. Zaffuto{dagger}, M. E. Piccone, T. G. Burrage, C. A. Balinsky{ddagger}, G. R. Risatti, M. V. Borca, L. G. Holinka, D. L. Rock§ and C. L. Afonso{dagger}

Plum Island Animal Disease Center, USDA-ARS, PO Box 848, Greenport, NY 11944, USA

Correspondence
C. L. Afonso
claudio.afonso{at}ars.usda.gov

Classical swine fever virus (CSFV)–macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (>2.5-fold, P<0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1beta. Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.

{dagger}Present address: USDA/ARS/SEPRL, 934 College Station Road, Athens, GA 30605, USA.

{ddagger}Present address: Department of Pathobiology, University of Connecticut, 61 N. Eagleville Road, Storrs, CT 06269, USA.

§Present address: Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 2522 Vet. Med. Basic Sciences Building, MC-002, 2001 S. Lincoln Avenue, Urbana, IL 61802, USA.






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