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Distinct gamma interferon-production pathways in mice infected with lactate dehydrogenase-elevating virus

Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Bruxelles, Belgium

Correspondence
Jean-Paul Coutelier
coutelier{at}mexp.ucl.ac.be

Two distinct pathways of gamma interferon (IFN-) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN- production and requires the secretion of interleukin-12. This regulation of IFN- production by type I interferons may help to control indirect pathogenesis induced by this cytokine.

This article has been cited by other articles:

				T. Le-Thi-Phuong, L. Dumoutier, J.-C. Renauld, J. Van Snick, and J.-P. Coutelier Divergent roles of IFNs in the sensitization to endotoxin shock by lactate dehydrogenase-elevating virus Int. Immunol., November 1, 2007; 19(11): 1303 - 1311. [Abstract] [Full Text] [PDF]