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Multiple recombinant dengue type 1 viruses in an isolate from a dengue patient

Katie Buzacott^1,

Emma Field^1,

¹ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
² Institute Pasteur, Noumea, New Caledonia
³ Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA
⁴ Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA

Correspondence
John Aaskov
j.aaskov{at}qut.edu.au

Between 2000 and 2004, dengue virus type 1 (DENV-1) genotypes I and II from Asia were introduced into the Pacific region and co-circulated in some localities. Envelope protein gene sequences of DENV-1 from 12 patients infected on the island of New Caledonia were obtained, five of which carried genotype I viruses and six, genotype II viruses. One patient harboured a mixed infection, containing viruses assigned to both genotypes I and II, as well as a number of inter-genotypic recombinants. This is the first report of a population of dengue viruses isolated from a patient containing both parental and recombinant viruses.

These authors contributed equally to this work.

A table showing oligonucleotide primers used for PCR or sequencing of the DENV-1 E genes, a chromatogram of the sequence of complementary-strand cDNA obtained following RT-PCR and a sequence alignment (NEXUS format) are available as supplementary material with the online version of this paper.

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