HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Parsyan, A. Articles by Candotti, D. Search for Related Content PubMed PubMed Citation Articles by Parsyan, A. Articles by Candotti, D. Agricola Articles by Parsyan, A. Articles by Candotti, D.

Identification and genetic diversity of two human parvovirus B19 genotype 3 subtypes

¹ Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK
² Department of Genetics, University of Cambridge, Cambridge, UK
³ National Blood Service, Cambridge Blood Centre, Cambridge, UK

Correspondence
Daniel Candotti
dc241{at}cam.ac.uk

Three genotypes (1–3) of human parvovirus B19 have been identified. Analysis of 13 nearly full-length genotype 3 sequences from Ghana, Europe and Brazil identified two genetically distinct clusters. The classification of genotype 3 strains into two subtypes (B19/3a and B19/3b) is proposed. The rate of evolutionary change of B19 genotype 3 strains (2x10^–4 nucleotide substitutions per site per year) was similar to those of B19 genotype 1 and carnivore parvoviruses, supporting the hypothesis that high mutation rates are characteristic of members of the family Parvoviridae. The estimated divergence time between B19/3a and B19/3b is 525 years. In Ghana, subtype B19/3a is predominant.

The GenBank/EMBL/DDBJ accession numbers for the Ghanaian B19 sequences obtained in this study are AY582124, AY582125, DQ234769, DQ234771, DQ234775, DQ234778 and DQ234779.

This article has been cited by other articles:

				J. M. Hubschen, Z. Mihneva, A. F. Mentis, F. Schneider, Y. Aboudy, Z. Grossman, H. Rudich, K. Kasymbekova, I. Sarv, J. Nedeljkovic, et al. Phylogenetic Analysis of Human Parvovirus B19 Sequences from Eleven Different Countries Confirms the Predominance of Genotype 1 and Suggests the Spread of Genotype 3b J. Clin. Microbiol., November 1, 2009; 47(11): 3735 - 3738. [Abstract] [Full Text] [PDF]

				P. Norja, A. M. Eis-Hubinger, M. Soderlund-Venermo, K. Hedman, and P. Simmonds Rapid Sequence Change and Geographical Spread of Human Parvovirus B19: Comparison of B19 Virus Evolution in Acute and Persistent Infections J. Virol., July 1, 2008; 82(13): 6427 - 6433. [Abstract] [Full Text] [PDF]

				B. Schneider, A. Hone, R. H. Tolba, H.-P. Fischer, J. Blumel, and A. M. Eis-Hubinger Simultaneous persistence of multiple genome variants of human parvovirus B19 J. Gen. Virol., January 1, 2008; 89(1): 164 - 176. [Abstract] [Full Text] [PDF]

				L. A. Shackelton, K. Hoelzer, C. R. Parrish, and E. C. Holmes Comparative analysis reveals frequent recombination in the parvoviruses J. Gen. Virol., December 1, 2007; 88(12): 3294 - 3301. [Abstract] [Full Text] [PDF]

				A. Ekman, K. Hokynar, L. Kakkola, K. Kantola, L. Hedman, H. Bonden, M. Gessner, C. Aberham, P. Norja, S. Miettinen, et al. Biological and Immunological Relations among Human Parvovirus B19 Genotypes 1 to 3 J. Virol., July 1, 2007; 81(13): 6927 - 6935. [Abstract] [Full Text] [PDF]