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J Gen Virol 88 (2007), 428-431; DOI 10.1099/vir.0.82496-0

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© 2007 Society for General Microbiology

Short Communication

Identification and genetic diversity of two human parvovirus B19 genotype 3 subtypes

Armen Parsyan1, Camille Szmaragd2, Jean-Pierre Allain1 and Daniel Candotti3

1 Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK
2 Department of Genetics, University of Cambridge, Cambridge, UK
3 National Blood Service, Cambridge Blood Centre, Cambridge, UK

Correspondence
Daniel Candotti
dc241{at}cam.ac.uk

Three genotypes (1–3) of human parvovirus B19 have been identified. Analysis of 13 nearly full-length genotype 3 sequences from Ghana, Europe and Brazil identified two genetically distinct clusters. The classification of genotype 3 strains into two subtypes (B19/3a and B19/3b) is proposed. The rate of evolutionary change of B19 genotype 3 strains (2x10–4 nucleotide substitutions per site per year) was similar to those of B19 genotype 1 and carnivore parvoviruses, supporting the hypothesis that high mutation rates are characteristic of members of the family Parvoviridae. The estimated divergence time between B19/3a and B19/3b is 525 years. In Ghana, subtype B19/3a is predominant.

The GenBank/EMBL/DDBJ accession numbers for the Ghanaian B19 sequences obtained in this study are AY582124, AY582125, DQ234769, DQ234771, DQ234775, DQ234778 and DQ234779.




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