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Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs

N. Stock^1,

¹ School of Biology, University of St Andrews, Fife KY16 9TS, UK
² Division of Basic Medical Sciences, St George's, University of London, London SW17 0RE, UK
³ CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220, Australia

Correspondence
R. E. Randall
rer{at}st-and.ac.uk

Mapuera virus (MPRV) is a paramyxovirus that was originally isolated from bats, but its host range remains unknown. It was classified as a member of the genus Rubulavirus on the basis of structural and genetic features. Like other rubulaviruses it encodes a V protein (MPRV/V) that functions as an interferon (IFN) antagonist. Here we show that MPRV/V differs from the IFN antagonists of other rubulaviruses in that it does not induce the proteasomal degradation of STAT proteins, key factors in the IFN signalling cascade. Rather, MPRV/V prevents the nuclear translocation of STATs in response to IFN stimulation and inhibits the formation of the transcription factor complex ISGF3. We also show that MPRV/V blocks IFN signalling in cells from diverse mammalian species and discuss the IFN response as a barrier to cross-species infections.

The sequence of Mapuera virus V/P gene was determined in this study (GenBank accession no. EF035449).

Present address: Dept Biochemistry, Molecular & Cell Biology, North-Western University, 2205 Tech Drive, Evanston, IL 60208-3500, USA.

This article has been cited by other articles:

				R. E. Randall and S. Goodbourn Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures J. Gen. Virol., January 1, 2008; 89(1): 1 - 47. [Abstract] [Full Text] [PDF]