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J Gen Virol 88 (2007), 1565-1567; DOI 10.1099/vir.0.82758-0

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Short Communication

A novel monolayer cell line derived from human umbilical cord blood cells shows high sensitivity to measles virus

Fumio Kobune1,2, Yasushi Ami3, Miki Katayama2, Motohide Takahashi3, Renchin Tuul4, Gulay Korukluoglu5, Tomoko Kiyohara3, Ryuichi Miura1, Hiroki Sato1, Misako Yoneda1 and Chieko Kai1

1 Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
2 NPO–Biomedical Science Association, Tokyo 169-0075, Japan
3 National Institute of Infectious Diseases (NIID), Tokyo 190-0011, Japan
4 National Center for Communicable Diseases, Ulaanbaatar 48, Mongolia
5 National Measles Laboratory, Virology Department, Refik Saydam National Hygiene Center, Ankara 18-06100, Turkey

Correspondence
Chieko Kai
ckai{at}ims.u-tokyo.ac.jp

Measles virus (MeV) research is largely dependent on the B95a cell line, which is derived from marmoset B lymphocytes. As this cell line is persistently infected with Epstein–Barr virus (EBV), a novel cell line, COBL-a, was established from human umbilical cord blood. COBL-a cells have a significant advantage over B95a cells because they are of human origin, are free from EBV and have higher sensitivity to wild-type MeV. Thus, COBL-a cells should prove very valuable for both epidemiological and basic studies of MeV.




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H. Sato, M. Masuda, M. Kanai, K. Tsukiyama-Kohara, M. Yoneda, and C. Kai
Measles Virus N Protein Inhibits Host Translation by Binding to eIF3-p40
J. Virol., November 1, 2007; 81(21): 11569 - 11576.
[Abstract] [Full Text] [PDF]


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