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Enterovirus surveillance reveals proposed new serotypes and provides new insight into enterovirus 5'-untranslated region evolution

Veronika Bubovia⁴

¹ Enterovirus Laboratory, Department of Viral Diseases and Immunology, National Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland
² Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520 Turku, Finland
³ National Reference Centres, Public Health Office of the Slovak Republic, Trnavska 52, 82645 Bratislava, Slovak Republic
⁴ State Agency ‘Public Health Agency’, Virology Laboratory, Klijanu Str. 7, LV-1012 Riga, Latvia
⁵ M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of Russian Academy of Medical Science, Kievskoe Shosse 27 km, 142782 Moscow Region, Russian Federation

Correspondence
Merja Roivainen
Merja.Roivainen{at}ktl.fi

Human enteroviruses are currently grouped into five species Human enterovirus A (HEV-A), HEV-B, HEV-C, HEV-D and Poliovirus. During surveillance for enteroviruses serologically non-typable enterovirus strains were found from acute flaccid paralysis patients and healthy individuals. In this study, we report isolates of recently described enterovirus types EV76 and EV90 of HEV-A species and characterize two new enterovirus type candidates, EV96 and EV97, to species HEV-C and HEV-B, respectively. Analysis of partial 3D regions of EV96 strains revealed sequence divergence consistent with several recombination events between EV96, other HEV-C viruses and polioviruses. Phylogenetic analysis of all available 5'-untranslated region sequences of human entero- and rhinovirus prototype strains and 10 simian enterovirus strains suggested interspecies recombination involving this region.

The GenBank/EMBL/DDBJ accession numbers of the sequences reported in this paper are EF364396–EF364423 and EF392677.

Supplementary material is available with the online version of this paper.

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				S. Blomqvist, A. Paananen, C. Savolainen-Kopra, T. Hovi, and M. Roivainen Eight Years of Experience with Molecular Identification of Human Enteroviruses J. Clin. Microbiol., July 1, 2008; 46(7): 2410 - 2413. [Abstract] [Full Text] [PDF]