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Effect of NMSO3 treatment in a murine model of human metapneumovirus infection

¹ Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA
² Microbiotix Inc., Worcester, MA, USA
³ Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA
⁴ Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, USA

Correspondence
Antonella Casola
ancasola{at}utmb.edu

BALB/c mice infected with human metapneumovirus (hMPV) were treated with the sulfated sialyl lipid NMSO3 (one dose of 50 mg kg^–1) given at the time of infection. NMSO3 significantly reduced viral replication in the lungs, as well as hMPV-induced body weight loss, pulmonary inflammation and cytokine production, suggesting that antiviral treatment initiated at the beginning of viral infection can modify hMPV-induced disease.