HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, A. C.-H. Articles by Antonsson, A. Search for Related Content PubMed PubMed Citation Articles by Chen, A. C.-H. Articles by Antonsson, A. Agricola Articles by Chen, A. C.-H. Articles by Antonsson, A.

Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure

Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia

Correspondence
Annika Antonsson
a.antonsson{at}uq.edu.au

Cutaneous human papillomavirus (HPV) has been widely detected in healthy skin. Previous studies have found that UV radiation can activate several HPV types, and a possible role for cutaneous HPV in the development of non-melanoma skin cancer has been suggested. This study investigated the prevalence and type-spectrum of cutaneous HPV in relation to UV radiation by studying forehead skin swab samples from 50 healthy males frequently exposed to the sun and 50 healthy males who were not frequently exposed to the sun. A questionnaire including ethnic background of the participants, history of cancers and a self-assessment of sun-exposure was also conducted and analysed. PCR with the FAP primer pair was carried out to detect HPV DNA in samples. HPV prevalence was higher in individuals who spent more time outdoors and in individuals with a history of skin cancers (P=0.044 and P=0.04, respectively). Furthermore, individuals wearing sunglasses as a means of sun protection had a lower prevalence of HPV (P=0.018). Interestingly, HPV-76 was only detected in the group without frequent sun-exposure (P=0.001). These results suggest that increased UV radiation exposure may be a factor leading to a difference in prevalence of cutaneous HPV types.

The GenBank/EMBL/DDBJ accession number for the partial L1 sequence of the putative new HPV type FADI1 is EU340869.

This article has been cited by other articles:

				E.-M. de Villiers and K. Gunst Characterization of seven novel human papillomavirus types isolated from cutaneous tissue, but also present in mucosal lesions J. Gen. Virol., August 1, 2009; 90(8): 1999 - 2004. [Abstract] [Full Text] [PDF]