J Gen Virol Try Microbiology Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 89 (2008), 3173-3176; DOI 10.1099/vir.0.2008/004150-0

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Colussi, S.
Right arrow Articles by Acutis, P. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Colussi, S.
Right arrow Articles by Acutis, P. L.
Agricola
Right arrow Articles by Colussi, S.
Right arrow Articles by Acutis, P. L.

Short Communication

Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats

Silvia Colussi1, Gabriele Vaccari2, Cristiana Maurella1, Cristina Bona1, Raniero Lorenzetti3, Pasquale Troiano4, Francesco Casalinuovo5, Alessandra Di Sarno6, Maria Grazia Maniaci1, Fabio Zuccon1, Romolo Nonno2, Cristina Casalone1, Maria Mazza1, Giuseppe Ru1, Maria Caramelli1, Umberto Agrimi2 and Pier Luigi Acutis1

1 Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, Torino, Italy
2 Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy
3 Istituto Zooprofilattico Sperimentale delle Regioni Lazio Toscana, Via Appia Nuova 1411, Rome, Italy
4 Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredoni 20, Foggia, Italy
5 Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Crotone, Catanzaro, Italy
6 Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Fanelli P.co dei Gerani, Caserta, Italy

Correspondence
Pier Luigi Acutis
pierluigi.acutis{at}izsto.it

Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie in sheep, with the alleles AHQ and AF141RQ strongly associated with occurrence of the disease. The presence of histidine at codon 154 has also been detected in Nor98-affected goats, but statistical analysis of the association between Nor98 and goat PRNP polymorphisms has not been reported previously. Here, a case–control study was carried out on eight Nor98-positive goats and 246 negative herdmates belonging to eight Italian Nor98 scrapie outbreaks. The results revealed that histidine at codon 154 is also strongly associated with the disease in goats.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2008 by the Society for General Microbiology.