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J Gen Virol 89 (2008), 1276-1281; DOI 10.1099/vir.0.83593-0

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Short Communication

Complete genome analysis of hepatitis C virus subtypes 6t and 6u

Suwanna Noppornpanth1, Yong Poovorawan2, Truong Xuan Lien3, Saskia L. Smits1, Albert D. M. E. Osterhaus1 and Bart L. Haagmans1

1 Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
2 Center of Excellence in Viral Hepatitis Research, Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand
3 Department of Biological Analysis, Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Vietnam

Correspondence
Bart L. Haagmans
b.haagmans{at}erasmusmc.nl

Hepatitis C virus (HCV) genomes exhibit high nucleotide sequence diversity. In this study, we performed complete genome sequence analysis of 11 HCV genotype 6 samples from Vietnam and Thailand. We identified nine HCV complete genomes belonging to subtypes 6a (D9), 6e (D42 and D88), 6f (TH52), 6i (TH24), 6l (D33), 6n (TH22 and TH31) and 6o (D85). Phylogenetic analysis of the core/E1 and NS5B regions from unclassified genotype 6 isolates from Asian immigrants in Canada revealed that two other viruses (D49 and D83) could be classified as novel candidates of HCV subtypes 6t and 6u.

The GenBank/EMBL/DDBJ sequence accession numbers for the sequences reported in this study are EU246930–EU246940.

Supplementary material is available with the online version of this paper.






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