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J Gen Virol 89 (2008), 1478-1484; DOI 10.1099/vir.0.2008/000364-0

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Short Communication

Small ruminant lentivirus proviral sequences from wild ibexes in contact with domestic goats

Esadk Erhouma1,2,3,4,5,6, François Guiguen1,2,3,4,5,6, Yahia Chebloune1,2,3,4,5,6,{dagger}, Dominique Gauthier7, Laila Mselli Lakhal1,2,3,4,5,6,{ddagger}, Timothy Greenland1,2,3,4,5,6, Jean François Mornex1,2,3,4,5,6,8, Caroline Leroux1,2,3,4,5,6 and Théodore Alogninouwa1,2,3,4,5,6

1 Université de Lyon, F-69007 Lyon, France
2 Université Lyon 1, F-69007 Lyon, France
3 INRA, UMR754 ‘Rétrovirus et Pathologie Comparée’, Lyon, France
4 Ecole Nationale Vétérinaire de Lyon, Lyon, France
5 Ecole Pratique des Hautes Etudes, Lyon, France
6 IFR128 BioSciences Gerland Lyon Sud, Lyon, France
7 Laboratoire Départemental Vétérinaire, Gap, France
8 Hospices Civils de Lyon, Lyon, France

Correspondence
François Guiguen
guiguen{at}univ-lyon1.fr

Small ruminant lentiviruses (SRLV) are widespread amongst domesticated goats and sheep worldwide, but have not been clearly identified in wild small ruminants, where they might constitute an animal health risk through contamination from local domesticates. SRLV proviruses from three ibexes from the French Alps are described and sequences from their gag gene and long terminal repeats (LTRs) were compared with sequences from local goats and goat/ibex hybrids. The ibex and hybrid proviruses formed a closely related group with <2 % nucleotide difference. Their LTRs were clearly distinct from those of local goats or reference SRLV sequences; however, their gag sequences resembled those from one local goat and reference sequences from caprine arthritis encephalitis virus rather than visna/maedi virus. One SRLV-positive ibex from a distant site shared similarities with the other ibexes studied in both its gag and LTR sequences, suggesting that a distinct SRLV population could circulate in some wild ibex populations.

{dagger}Present address: MMD Lab of Viral Pathogenesis, University of Kansas Medical Center, 5000 WHE, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.

{ddagger}Present address: UR66, Pharmacologie et Toxicologie, INRA-180 Chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France.

The GenBank/EMBL/DDBJ accession numbers for the gag and LTR sequences, respectively, reported in this paper are EU375926–EU375932 and EU375968–EU375971 for ibex #1; EU375933–EU375937 and EU375972–EU375973 for ibex #2; EU375938–EU375941 and EU375974–EU375976 for ibex #3; EU375942–EU375945 and EU375977–EU375979 for hybrid #1; EU375946–EU375951 and EU375980–EU375982 for hybrid #2; EU375952–EU375953 and EU375983–EU375985 for hybrid #3; EU375954–EU375958 and EU375986–EU375988 for goat #1; EU375959–EU375961, EU526865 and EU375989–EU375991 for goat #2; and EU375962–EU375967 for goat #3.






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